Interest:Yes!! Mostly because I love playing with the whole identity crisis aspect of games like this. And I have a weakness for the crazy au families that can be set up in this kind of setting.
Location: I don't think the location matters much. More importantly, put various location types nearby. (Like a beach, forest or nature type area, amusement park, etc.) This will give a lot of options for the players.
Anything else: Make memory echoes easier to get. Echoes that grant skills or powers or other advantages should require approval, but I feel like simple memory echoes are better left up to the players. That way threads don't get held up while players wait to see if their characters remember that time they had coffee.